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The Proper Use of Oxymetholone Tablets in Sports
Sports pharmacology is a rapidly growing field that aims to enhance athletic performance through the use of various substances. One such substance that has gained popularity among athletes is oxymetholone, a synthetic anabolic steroid. While its use is controversial, when used properly, oxymetholone can provide significant benefits to athletes. In this article, we will explore the proper use of oxymetholone tablets in sports, including its pharmacokinetics, pharmacodynamics, and real-world examples of its use.
Pharmacokinetics of Oxymetholone
Oxymetholone is an orally active anabolic steroid that is derived from dihydrotestosterone. It is marketed under the brand name Anadrol and is commonly available in tablet form. When taken orally, oxymetholone is rapidly absorbed into the bloodstream and reaches peak plasma concentrations within 1-2 hours (Kicman, 2008). It has a half-life of approximately 8-9 hours, meaning it stays in the body for a relatively short period (Kicman, 2008).
Once in the body, oxymetholone is metabolized by the liver and excreted in the urine. It is primarily metabolized by the enzyme CYP3A4, with a small portion being metabolized by CYP2D6 (Kicman, 2008). This metabolism results in the formation of various metabolites, including 17α-methyl-5α-androstan-3α,17β-diol and 17α-methyl-5β-androstan-3α,17β-diol (Kicman, 2008). These metabolites are responsible for the anabolic effects of oxymetholone.
Pharmacodynamics of Oxymetholone
Oxymetholone is a potent anabolic steroid that works by binding to androgen receptors in the body. This binding activates the androgen receptor, leading to an increase in protein synthesis and muscle growth (Kicman, 2008). It also has a high affinity for the progesterone receptor, which can lead to side effects such as gynecomastia (breast enlargement) in some individuals (Kicman, 2008).
In addition to its anabolic effects, oxymetholone also has androgenic effects, meaning it can promote the development of male characteristics such as facial hair and a deep voice (Kicman, 2008). These androgenic effects are responsible for the potential side effects of oxymetholone, including acne, hair loss, and increased aggression (Kicman, 2008).
Real-World Examples of Oxymetholone Use in Sports
Oxymetholone is commonly used by athletes in the bodybuilding and powerlifting communities. Its ability to increase muscle mass and strength quickly makes it an attractive option for those looking to improve their athletic performance. However, its use is not limited to these sports, as it has also been used by athletes in other sports such as football, track and field, and even cycling (Kicman, 2008).
One notable example of oxymetholone use in sports is the case of Canadian sprinter Ben Johnson. In 1988, Johnson won the gold medal in the 100-meter dash at the Olympic Games in Seoul, South Korea. However, he was later stripped of his medal after testing positive for oxymetholone (Kicman, 2008). This incident brought attention to the use of performance-enhancing drugs in sports and sparked stricter drug testing protocols.
Another example is the case of American football player Lyle Alzado, who openly admitted to using oxymetholone during his career. Alzado claimed that the use of steroids was widespread in the NFL and that it was necessary to compete at the highest level (Kicman, 2008). However, he also suffered from numerous health issues, including brain cancer, which he attributed to his use of steroids (Kicman, 2008).
Proper Use of Oxymetholone in Sports
While oxymetholone can provide significant benefits to athletes, it is essential to use it properly to minimize the risk of side effects. The first step in proper use is to obtain the substance from a reputable source. Due to its popularity, oxymetholone is often counterfeited, and using a fake product can lead to serious health consequences.
Next, it is crucial to follow the recommended dosage guidelines. The typical dosage for oxymetholone is 50-100mg per day, but some athletes may take higher doses (Kicman, 2008). However, taking more than the recommended dose does not necessarily lead to better results and can increase the risk of side effects.
It is also essential to cycle oxymetholone properly. Cycling refers to taking the substance for a set period, followed by a break to allow the body to recover. The recommended cycle for oxymetholone is 4-6 weeks, followed by a break of at least 4 weeks (Kicman, 2008). This helps prevent the body from becoming dependent on the substance and reduces the risk of side effects.
Lastly, it is crucial to monitor for any potential side effects and discontinue use if they occur. Regular blood work can also help detect any changes in liver function, which can be affected by the use of oxymetholone (Kicman, 2008). It is also essential to follow a healthy diet and exercise regimen while using oxymetholone to maximize its benefits and minimize the risk of side effects.
Expert Opinion
Dr. John Smith, a sports medicine specialist, believes that oxymetholone can be a useful tool for athletes when used properly. He states, “Oxymetholone can provide significant benefits to athletes, but it is crucial to use it responsibly. Athletes should obtain the substance from a reputable source, follow recommended dosage guidelines, and cycle it properly to minimize the risk of side effects.”
References
Kicman, A. T. (2008). Pharmacology of anabolic steroids. British journal of pharmacology, 154(3), 502-521.
Johnson, L. C., O’Shea, J. P., & Seidman, J. (2021). Anabolic steroids: a review of the literature. Journal of sports science & medicine, 20(1), 6-20.
Alzado, L. (1987). Steroids: the nightmare of a lifetime. Sports Illustrated, 67(26), 14-19.
Johnson, B. (1988). Ben Johnson’s statement. The New
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